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KMID : 0385020000160010015
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Korean Journal of Laboratory Animal Science
2000 Volume.16 No. 1 p.15 ~ p.22
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Comparative Studies on lymphatic Organ of Mongolian Gerbil and Sprague-Dawley Rat Followed by Continuous Water Deprivataion
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김환묵/Kim, Hwan Mook
한상배/이기훈/이철호/현병화/김무강/송치원/Han, Sang Bae/Lee, Ki Hoon/Lee, Chul Ho/Hyun, Byung Hwa/Kim, Moo Kang/Song, Chi Won
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Abstract
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Mogolian gerbil (Meriones unguiculatus, gerbil) has been used as a laboratory model animal of neurological diseases due to the congenitally incomplete Willis circle in the brain base and long live after continuous water deprivation. Gerbil has the stringent water metabolism so that it can survive more than 45 days with only small amount of water integrated in food or produced in catabolic metabolism in the absence of water supply. In the present studies, we examined histological changes of gerbil followed by water deprivation in comparison with Spraque-Dawley rat (Rattus norvegicus, SD rat). The results obtained were summarized as follows,
1. In the water deprived SD rat and gerbil during 11 days, The number of lymphocytes was decreased and the shape of the lymphatic nodule and medulla were observed more irregularly than normal SD rat and gerbil, as control.
2. The number of thymocyte of cortex of the SD rat and gerbil thymus after water deprived 11 th days was severe decreased than nornlal SD rat and gerbil.
3. The number of lymphocyte and shapes of white pulp and red pulp on SD rat and gerbil spleen during water deprived 11th days was decreased and more irregular than normal SD rat and gerbil spleen.
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